Mutational sources of trans-regulatory variation affecting gene expression in Saccharomyces cerevisiae

Heritable variation in a gene’s expression arises from mutations impacting cis - and trans -acting components of its regulatory network. Here, we investigate how -regulatory are distributed within the genome gene network by identifying characterizing 69 with effects on same focal Saccharomyces cerevisiae . Relative to 1766 without this gene, found that these were enriched coding sequences transcription factors previously predicted regulate gene. However, over 90% identified mapped other types genes involved diverse biological processes including chromatin state, metabolism, signal transduction. These data show genetic changes can impact , revealing properties provide raw material for segregating natural populations.